Selected publications.
2024
Hussain N, Apotikar A, Pidathala S, Mukherjee S, Burada AP, Sikdar SK, Vinothkumar KR, Penmatsa A. Cryo-EM structures of pannexin 1 and 3 reveal differences among pannexin isoforms. Nat Commun. (2024);15(1) :2942.
2023
Majumder, P., Ahmad, S., Ahuja, P., Athreya, A., Ranjan, R. & Penmatsa, A. CryoEM structure of antibacterial efflux transporter QacA in Staphylococcus aureus reveals allosteric role of a novel extracellular loop. EMBO J (2023) e113418
Nayak, S.R., Joseph, D., Hoefner, G., Dakua, A., Athreya, A., Wanner, K.T., Kanner, B.,& Penmatsa, A. CryoEM structure of GABA transporter 1 reveals substrate recognition and transport mechanism.
Nat. Str. Mol. Biol. (2023) (https://doi.org/10.1038/s41594-023-01011-w)
Nat. Str. Mol. Biol. (2023) (https://doi.org/10.1038/s41594-023-01011-w)
2022
Joseph, D., Nayak, S.R. & Penmatsa, A. Structural insights into GABA transport inhibition using an engineered neurotransmitter transporter. EMBO J. (2022).e110735, 1-17. (https://doi.org/10.15252/embj.2022110735)
Penmatsa, A. A (Fab)ulous tool to block efflux. Nat. Chem. Biol. (2022).https://doi.org/10.1038/s41589-022-00999-4 (News and Views article)
2021
Dubey, S., Majumder, P., Penmatsa, A. & Sardesai, A.A. Topological analyses of the L-lysine exporter LysO reveal a critical role for a conserved pair of intramembrane solvent-exposed acidic residues. J. Biol. Chem. (2021). 297(4), 101168.
Kumar. S., Athreya, A., Gulati, A., Nair, R.M., Mahendran, I., Ranjan, R. & Penmatsa, A. Structural basis of inhibition of a transporter from Staphylococcus aureus, NorC, through a single-domain camelid antibody. Commun Biol. (2021) 4, 836. (https://doi.org/10.1038/s42003-021-02357-x)
Shabareesh, P., Mallela, A.K., Jospeh, D. & Penmatsa, A. Structural basis of norepinephrine recognition and transport inhibition in neurotransmitter transporters. Nat Commun. (2021) 12, 2199. (https://doi.org/10.1038/s41467-021-22385-9)
2020
Khatri, B., Majumder, P., Nagesh, J., Penmatsa, A., & Chatterjee, J. Increasing protein stability by engineering n to pi* interaction at the beta-turn. Chem. Sci. (2020). 11, 9480-9487. (DOI: 10.1039/D0SC03060K)
Kumar, S., Ithayaraja, M., Athreya, A., Ranjan, R., & Penmatsa, A. Isolation and structural characterization of a Zn2+-bound single-domain antibody against NorC, a putative multi-drug efflux transporter in bacteria. J. Biol. Chem. (2020). 295 (1), 55-68.
2019
Joseph, D., Mallela, A.K., Pidathala, S., & Penmatsa, A. Structure and gating dynamics of Na+/Cl- coupled neurotransmitter transporters. Front. Mol. Biosci. (2019). 6, 80. (doi: 10.3389/fmolb.2019.00080)
Majumder, P., Khare, S., Athreya, A., Hussain, N., Gulati. A., & Penmatsa, A. Dissection of protonation sites for antibacterial recgonition and transport in QacA, a multi-drug efflux transporter. J. Mol. Biol. (2019). 431, 2163-2179.
2018
Majumder, P., Mallela, A. K., & Penmatsa, A. Transporters through the looking glass: An insight into the mechanisms of ion-coupled transport and methods that help reveal them. J. Indian. Inst. Sci. (2018). 98, 283-300. (invited review).
Prior to joining IISc (2015 and earlier).
1. Penmatsa, A.*, Wang, K. H.*, & Gouaux, E. X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine. Nat. Struct. Mol. Biol. (2015). 22, 506-508.
2. Wang, K. H.*, Penmatsa, A.* & Gouaux, E. Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature. (2015). 521, 322–327.
3. Wang, H., Goehring, A., Wang, K. H., Penmatsa, A., Ressler, R. & Gouaux, E. Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature. (2013). 503, 141-145.
4. Penmatsa, A.*, Wang, K. H.* & Gouaux, E. X-ray structure of dopamine transporter elucidates antidepressant mechanism. Nature. (2013). 503, 85-90.
5. Aravind, P.*, Mishra, A.*, Suman, S. K.*, Jobby, M. K., Sankaranarayanan, R. & Sharma, Y. The betagamma-Crystallin superfamily contains a universal motif for binding calcium. Biochemistry. (2009), 48, 12180–12190.
6. Aravind, P., Chandra, K., Reddy, P. P., Jeromin, A., Chary, K. V. & Sharma, Y. Regulatory and Structural EF-hand motifs of Neuronal Calcium Sensor-1: Mg2+ modulates Ca2+-binding, Ca2+-Induced conformational changes, and equilibrium unfolding transitions. J. Mol. Biol. (2008), 376, 1100-1115.
(* indicates equal contribution)